In three mouse models of PCa, PB-MYC, ERG/PTENandTRAMP, we discovered the composition of the stroma is unique
In three mouse models of PCa, PB-MYC, ERG/PTENandTRAMP, we discovered the composition of the stroma is unique. inPB-MYCandERG/PTENtumors, whereas inTRAMPPCa they expand small and stromal cells invade into intraductal adenomas. Fate mapping of SMCs demonstrated that inPB-MYCtumors the cells are depleted, whereas they expand inTRAMPtumors Asapiprant and interestingly contribute to the stromal cells in intraductal…