However, molecular relationships and signaling events following CXCL11 or CXCL12 binding to CXCR7 remain poorly defined and controversial
However, molecular relationships and signaling events following CXCL11 or CXCL12 binding to CXCR7 remain poorly defined and controversial. Several reports suggest that CXCR7, despite conserving most of the canonical GPCR features, does not activate Gi-mediated pathways that are standard for chemokine receptors and would result in DPCPX GTP hydrolysis, calcium mobilization, and chemotaxis [2], [3],…