The RNase H assays carried out in presence of T/P trap showed the disappearance of the secondary cuts for both enzymes used here

The RNase H assays carried out in presence of T/P trap showed the disappearance of the secondary cuts for both enzymes used here. these enzymes remain susceptible to TDRTIs. Similar to WT RT, the N348I RT is definitely inhibited by EFdA primarily at the point of incorporation through decreased translocation. In addition, the N348I substitution…

However, molecular relationships and signaling events following CXCL11 or CXCL12 binding to CXCR7 remain poorly defined and controversial

However, molecular relationships and signaling events following CXCL11 or CXCL12 binding to CXCR7 remain poorly defined and controversial. Several reports suggest that CXCR7, despite conserving most of the canonical GPCR features, does not activate Gi-mediated pathways that are standard for chemokine receptors and would result in DPCPX GTP hydrolysis, calcium mobilization, and chemotaxis [2], [3],…