The lysosomal accumulations of TSC2 become more apparent upon amino acid removal (arrowheads, Appendix?Fig S4C)
The lysosomal accumulations of TSC2 become more apparent upon amino acid removal (arrowheads, Appendix?Fig S4C). withdrawal (Demetriades cells retain elevated TORC1 activity upon the removal of amino acids. This effect is specific for the eIF4A\containing eIF4F complex and not a general consequence of blocked translation. We observe a physical association between TORC1 and translation complexes,…